| | FEBRUARY 20249for the rigorous demands of contemporary biological research.Using Teams and/or OneNote, or another platform such as Google Classroom, students are provided with a table of "variants of concern" of SARs-CoV-2 which shows several variants (Beta, Gamma, Delta, Omicron etc.) plus details of known spike mutations of interest in each variant. These data can be taken from the UK Covid-19 Genomics UK Consortium website. For extra stretch, students can be asked to find the variants themselves. Students are then assigned a SARs-CoV-2 variant and guided with a set of tasks which requires them to integrate data from the RSC protein database, their textbooks, notes and other information given on Teams which serves as a hub where students and teachers can seamlessly interact, share resources, and engage in discussions about the tasks.Example Tasks1. Look at your SARs-CoV-2 variant and the mutations that have caused amino acid changes in the spike protein. Describe how the mutation changes the amino acid and therefore the protein (i.e. what does e.g. K417N mean and how is it different to K417T?) 2. Think about what these will do to the structure (e.g. has an R group changed so a bond holding the tertiary structure now does not exist, or might there be a new and inappropriate bond?)3. How might this affect the virus?4. How might this alter the effectiveness of vaccines?5. Based on the information you can get from the RCSB Protein Databank, can you identify where the mutation is on the structure and does this give a further insight into how it might change the virus?The digital bulletin board Padlet is then used to allow students to collaboratively curate and share their findings, with each having their own editable space. It is an ideal platform for showcasing their research, highlighting their findings of the SARs-CoV-2 variant researched and adding any multimedia resources they have discovered. As teachers we can use Padlet to spark discussions, pose open-ended questions, and encourage students to share relevant articles, videos, or images related to their project work. The platform's flexibility enables students to express their understanding of the complex biological concepts behind mutations that alter the structure of the spike protein in a creative way and empowers them to take ownership of their learning journey. Students also can be given a pdf copy of all the research achieved by the class.The integration of technology in Sixth Form Biology classrooms has the potential to transform the learning experience for both educators and students. Abstract concepts can be brought to life through interactive simulations and virtual experiments and students can explore complex biological processes. This approach also enables teachers to differentiate instruction effectively, catering to diverse learning styles and abilities within the same classroom. These resources not only make the learning process more engaging but also allow students to revisit and review complex concepts at their own pace, reinforcing their understanding of key biological principles. In the tapestry of Sixth Form Biology education, these technological tools weave a narrative of empowerment, curiosity, and excellence.Ensuring that educators are well-versed in the use of technology tools and pedagogical approaches is crucial for maximizing the benefits these can bring. Embracing and using these technologies can prepare students for the challenges of the modern scientific landscape while fostering a passion for discovery and lifelong learning.3-D model of the spike protein from SARs-CoV-2 taken from the RCSB Protein Databank Here at Benenden School we are using technology in the Biology classroom not just to deliver content, but to facilitate personalised learning experiences for all students
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